Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity

Abstract

Fibroblast growth factor-21 (FGF21) is a novel endocrine and paracrine regulator of metabolic homeostasis. The aim of our study was to measure its serum concentrations in patients with obesity, obesity and type 2 diabetes mellitus and healthy subjects, and to assess the changes of its circulating levels and mRNA expression after dietary and pharmacological interventions.

Keywords

• Beta-cell function
• ppar-alpha
• insulin-resistance
• metabolic syndrome
• adipose-tissue
• fibroblast-growth-factor-21
• fgf-21
• homeostasis
• adiponectin
• hormones