Serum concentrations of fibroblast growth factor 19 in patients with obesity and type 2 diabetes mellitus: the influence of acute hyperinsulinemia, very-low calorie diet and PPAR-alpha agonist treatment

Abstrakt

The aim of our study was to measure serum concentrations of fibroblast growth factor 19 (FGF-19) in patients with obesity (OB), obesity and type 2 diabetes mellitus (T2DM) and healthy subjects (C) at baseline and after selected interventions. FGF-19 levels in our study were at least partially dependent upon nutritional status, but were not related to parameters of glucose metabolism or insulin sensitivity.

Klíčová slova

• FGF-19
• Obesity
• type 2 diabetes mellitus
• very low calorie diet
• fenofibrate
• farnesoid-x-receptor
• bile-acid synthesis
• adipose-tissue
• insulin sensitivity
• metabolic-rate
• mice
• fibroblast-growth-factor-19
• homeostasis
• activation
• expression