Microscopic methods for the differentiation of lytic metastatic carcinoma and multiple myeloma

Abstract

Today, we have the possibility to use the following examination methods for palaeopathologic specimens: scanning electron microscopy (SEM), classic light histology using semi-thin Epon sections, stained by toluidine blue (LH), and laser confocal scanning microscopy (LCSM). Samples from two cases are described to demonstrate the microscopic distinction between osteolytic metastases of carcinoma and multiple myeloma.

Keywords

• Scanning electron microscopy
• Light histology using semi-thin sections
• Laser confocal electron microscopy
• Osteolytic metastases of carcinoma
• Multiple myeloma