Are Fli1, EKLF, PU.1, HDM2 and TP53 factors implicated in refractory anemia and megakaryopoiesis in 5q- syndrome
Abstrakt
In 5q-syndrome refractory anemia contrasts effective megakaryopoiesis. Erythroid and megakaryocytic cells share a common progenitor - MEP.
In experimental studies the differentiation of MEP is regulated by two transcription factors EKLF and Fli1.