Transcribed DNA is preferentially located in the perichromatin region of mammalian cell nuclei

Abstract

In cooperation with the University in Lausanne, high-resolution distribution of in-situ hybridization signal co-localizing with both transcriptionally active genes and their polyadenylated RNA sequence was analyzed. It was demonstrated that these genes are localized particularly in perichromatin area where transcription takes place.

Keywords

• Transcribed DNA
• Nuclear architecture
• Ultrastructural
• In situ hybridization
• Perichromatin region