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Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice

Publication at First Faculty of Medicine |
2010

Abstract

The N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) a N1-acetyl-5-methoxy-kynuramine (AMK) pathways of melatonin metabolism were investigated both in mice and humans. Metabolomic analysis did identify novel metabolites of AMK, i.e. hydroxy-AMK and glucuronide-conjugated hydroxy-AMK only in mice.

These data suggest that AFMK/AMK formation is not a significant pathway of melatonin disposition in mice.