The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic sclerosis

Abstract

These data demonstrate that JunD is overexpressed in SSc and that JunD is a mediator of the profibrotic effects of TGFbeta. Considering that inhibitors of AP-1 signalling have recently been These data demonstrate that JunD is overexpressed in SSc and that JunD is a mediator of the profibrotic effects of TGFbeta.

Considering that inhibitors of AP-1 signalling have recently been developed and are available for clinical trials in SSc, these findings may have translational implications.

Keywords

• EXTRACELLULAR-MATRIX
• DERMAL FIBROSIS
• STELLATE CELLS
• PROTEIN-1
• SCLERODERMA
• EXPRESSION
• MECHANISMS
• INHIBITOR
• APOPTOSIS
• PROTECTS