Electronic and vibrational optical activity of several peptides related to neurohypophyseal hormones: Disulfide group conformation

Abstract

Electronic and vibrational optical activity of the set of neurohypophyseal hormones and their analogs was investigated to clarify the S-S bond solution conformation. The selected compounds include oxytocin (I), lysine vasopressin (II), arginine vasopressin (III), and their analogs (IVIX), differing widely in their pharmacological properties.

We have extended the already known electronic circular dichroism data by new information provided by vibrational circular dichroism (VCD) and Raman optical activity (ROA).

Keywords

• neurohypophyseal hormones
• disulfide bridge
• chiroptical spectroscopy
• circular dichroism
• Raman optical activity
• vibrational circular dichroism
• oxytocin
• vasopressin
• analogs
• conformation