Brain reward system links to structures responsible for the control of motivation. Beside the receptor system monitoring the composition of the internal enviroment (chemoreceptors and mechanoreceptors in body organs, hypothalamic chemoreceptors) brain reward system includes connecting pathways and integration circuits in the hypothalamus, amygdala, septum, reticular formation, and orbitofrontal cortex.
Output of this system into the cerebral cortex controls the specific modulation of the behavious - motivation and drive to accomplish basic biological needs of the organism.