Surface Modification of Cyclic Olefin Copolymers for Osteochondral Defect Repair Can Increase Pro-Destructive Potential of Human Chondrocytes In Vitro

Abstract

Cycloolefin copolymers and their blends may represent suitable materials for tissue engineering, however, their surface modification followed by collagen type II application may, at least under in vitro conditions, reduce the viability of chondrocytes and induce their pro-destructive behavior.

Keywords

• Osteochondral defects
• Cycloolefin copolymer
• Chondrocytes
• Biocompatibility