Role of oncogenic microRNA miR-17-92 and miR 155 in hematopoiesis and leukemia

Abstrakt

Hematopoietic differentiation is highly ordered multistep process, where generation of terminal blood cells is dependent upon coordinated regulation of gene expression by key regulators: transcription factors and mikroRNAs.

Klíčová slova

• microRNA
• miR-17-92
• miR-155
• PU.1
• Egr2
• differentiation
• repression