Abstract
Giant-cell lesions of bone-neoplastic and reactive growths form a group of clinicopathological entities that differ in their behaviour and may present substantial problems in differential diagnosis. The presence of multinucleated giant cells of the osteoclast type, reactive osteoplasia and the formation of secondary aneurysmal cysts in many unrelated lesions of bone further complicates their classification.
Clinicopathologic correlation of all findings, including the radiologic features and laboratory tests, is of paramount importance in reaching a correct diagnosis in this group of histologically overlapping entities. Malignant features can be identified in the primary and secondary conventional malignant giant cell tumours and in some types of osteosarcoma with a giant cell component.