Identification of Mutated Srebf1 as a QTL Influencing Risk for Hepatic Steatosis in the Spontaneously Hypertensive Rat

Abstract

Genetic correction of deficient SREBP-1 activity by derivation of congenic and transgenic strains of SHR increased hepatic cholesterol levels, thereby establishing Srebf1 as a QTL influencing hepatic lipid metabolism in the rat

Keywords

• Srebf1c
• SHR
• hepatic cholesterol