Microvascular reactivity and skin autofluorescence and its relationship to glycemic variability in Type 1 diabetic patients with and without complications
Abstract
The aim of the study was to compare different parameters of glycemic variability (GV) calculated from either continual glucose monitoring (CGMS) or self-monitored blood glucose (SMBG) in patients with Type 1 DM (T1DM) with and without retinopathy and with normal and impaired vibration perception treshold (VPT, a measure of neuropathy) and to evaluate relationship of these parameters to microvascular reactivity (MVR) and skin autofluorescence (SAF). SAF reflects the formation of advanced glycation end-products (AGEs) and their accumulation in the skin.
Urinary albumin to creatinine ratio (UACR) was measured to evaluate nephropathy.