Stimulation of Protective and Cross-Protective Immunity against Influenza B Virus after Adjuvant Mucosal Immunization of Mice

Abstract

Intratracheal immunization of mice with inactivated influenza B virus and delipidated Bacillus firmus as adjuvant increases protection of mice against infection with the homologous virus strain and induces cross-protection: mice immunized by influenza virus B/Yamanashi 166/98 were protected even against phylogenetically distant virus drift variant B/Lee/40 lethal for mice.

Keywords

• adjuvant
• immunization
• influenza B virus
• protective
• immunity