Charles Explorer logo
🇬🇧

Biological drugs in hematooncology

Publication at First Faculty of Medicine |
2012

Abstract

Rituximab is one of the first monoclonal antibodies that have penetrated into clinical use. It is a chimeric antibody, where the heavy chain and the constatnt part of light chain consists of human immunoglobulin, while the variable light chain is of mouse origin ...

Alemtuzumab is a humanized antibody against the CD52 antigen. This antigen is present on B and T lymphocytes, but also on mature granulocytes ...

Gemtuzumab ozogamicin is an anti-CD33 antibody with bonded enediyn antibiotic kalicheamycin ... Ibritumomab tiuxetan is an anti-CD20 antibody with chelator, through which it is possible to conjugate it with the radioactive isotope ...

Ofatumumab is a fully human anti-CD20 antibody ...