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Production of Clinical Grade Mesenchymal Stromal Cells

Publication at First Faculty of Medicine |
2011

Abstract

Mesenchymal stromal cells (MSC, MSCs) are cells firstly described 35 years ago in bone marrow but present basically in all adult and fetal tissues, where they reside in the vessel wall as part of the population of pericytes. In the vessel wall as part of the population of pericytes.

These rare cells (10-6-10-4 of nucleated cells in various tissues received special attention of biomedical researchers as they are easy to expand and able to differentiate in various cell and tissue types. Later, these cells were found to be little immunogenic and to have immunosuppressive properties, which they exert by action on T cells, B cells, NK cells and dendritic cells ...