Limited walking ability significantly contributes to a loss of bone mineral density in the proximal femur in premenopausal and postmenopausal women with multiple sclerosis

Abstract

The aim of the study was to assess changes in bone mineral density (BMD) in relation to VDR gene polymorphisms (Bsm-I and Fok-I), motor deficit and glucocorticoid treatment in multiple sclerosis (MS) patients without osteoporosis supplemented with vitamin D and calcium and MS patients with osteoporosis treated with risedronate.

Keywords

• Multiple sclerosis
• osteoporosis
• polymorphism vitamin D receptor gene
• glucocorticoids
• motor deficit