Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition

Abstract

Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the interaction between a variably glycosylated envelope glycoprotein (gp120) and host-cell receptors. Differential glycosylation of gp120 affected envelope recognition by polyclonal antibodies from the sera of HIV-1-infected subjects.

These results indicate that gp120 glycans contribute to antibody reactivity and should be considered in HIV-1 vaccine design.

Keywords

• HIV-1
• n-linked glycosylation
• human immunodeficiency virus
• immune responses