The study presented in this paper had several goals which tried to contribute to the solution of selected research questions relevant for economy-wide material flow analysis. These goals were principally fourfold: (I) Quantification of EW-MFA indicators for the Czech Republic for 1990-2002, analysis of their trends and their international comparison; (II) Application of these indicators in a decoupling analysis and analysis of material intensity, international comparison of these phenomena and suggestion of methodology for graphical representation of decoupling; (III) Quantification of the net additions to stock indicator using both the direct and indirect methods of calculation and comparison of results obtained using these two approaches; (IV) Quantification of uncertainties related to the EW-MFA indicators calculated for the Czech Republic.