Low circulating Dickkopf-1 and its link with severity of spinal involvement in diffuse idiopathic skeletal hyperostosis

Abstract

Dickkopf-1 (DKK-1) is an inhibitor of osteoblastogenesis, and its lower levels are linked to new bone formation. We have found that the levels of serum DKK-1 were significantly lower in patients with DISH than in healthy controls and were associated with more severe spinal involvement.

Keywords

• Dickkopf-1 (DKK-1)
• diffuse idiopathic skeletal hyperostosis
• osteoblastogenesis
• spinal involvement