Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

Abstract

Our data provided increased support for previously identified risk loci at 5p15 (P 7.2 10(16)), 6p21 (P 2.3 10(14)) and 15q25 (P 2.2 10(63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region.

Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P 3.0 10(7)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer.

Keywords

• genome-wide association
• coronary-artery-disease
• dna double-strand
• susceptibility loci
• large-scale
• japanese population
• genotype imputation
• nicotine dependence
• in-vivo
• variants