Are the antimuscarinic drugs same effective and safe at elderly people in the treatment of overactive bladder?

Abstract

The present paper reviews current data on efficacy and risks (adverse drug events, ADE) of antimuscarinics. Attention is given to possible adverse central anticholinergic drug events of antimuscarinics, providing information of pharmacochemical properties of individual drugs that determine brain penetration and their possible CNS ADE.

Keywords

• overactive bladder
• aging
• geriatric frailty syndrome
• polymorbidity
• antimuscarinic drugs
• adverse drug events
• central anticholinergic effect
• cognitive performance