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Comparison of hepcidin adsorption to different types of magnetic particles prior MALDI-TOF analysis

Publication

Abstract

Hepcidin is the key regulator of iron metabolism and changes in the hepcidin level are associated with several diseases. Determination of the hepcidin content could therefore be useful in diagnosis of iron disorders and would provide further insight into hepcidin regulation in vivo.

Aim of the present study was to compare several magnetic sorbents with different coating matrix and/or with different terminal functionalized groups in their ability to adsorb hepcidin prior mass spectrometric analysis.