In most clinical situations, the main pillars of pharmacotherapy are antihypertensive regimens based on the inhibition of the renin-angiotensin-aldosterone system using a calcium channel bloker in combination with a statin as hypolipidemic therapy. This approach with demonstrated synergistic effects is surely not universal, but will be suitable for a large group of patients as both pimary and secondary prevention of circulatory complications of atherosclerosis.