The impact of extracorporeal life support and hypothermia on drug disposition in critically ill infants and children

Abstract

ECMO support is an established life saving therapy for potentially reversible respiratory and/or cardiac failure. Pharmacokinetic and pharmacodynamic data in neonates and older children on ECMO are sparse.

Most studies show altered volume of distribution and clearance for the drugs studied.

Keywords

• respiratory failure
• cardiac failure
• neonates