Toxicology new "legal recreational drugs": empatogeny / entactogens - analogues of "ecstasy" (MDMA) and from groups Aminoindan aminotetralinu
Abstract
Legal recreational drugs are new synthetic psychoactive substances with stimulant, hallucinogenic, empathogenic, sedative or combined effect not listed in the controlled psychotropic substances. The new "legal" analogues of MDMA (ecstasy) include substances from chemical groups of aminoindanes and aminotetralines (MMAI, MDAT, MDMAT).
They are potent selective serotonin releaser, to a much lesser extent, dopamine and norepinephrine releasers with particular empathogenic/entactogenic effect. The data on the absence of serotonin toxicity of new compounds are based on the studies in animals and cell cultures, yet no studies on the neurotoxicity of these compounds in humans are known.
Given that reliable information on the toxicity and treatment of the acute poisonings with new psychoactive substances is very limited, the treatment should be focused pragmatically on the current status of the patient and essentially extrapolated from experience with the treatment of acute MDMA and stimulants intoxication.