Publication at First Faculty of Medicine |
2009
Abstract
Germline mutations in either the BRCA1 or BRCA2 gene account for approximately from five toten percent of breast cancers in population. Breast cancer caused by mutations of BRCA1 a BRCA2 genes have usually different histopatologic characteristics and als different biological behaviour.
Individualization of therapy based on the knowledge of the molecular prognostic and predictive markers is goal of modern oncologic treatment, and BRCA1 and BRCA2 expression might be one of them.