INVESTIGATION OF THYROID DISORDER IN PREGNANCY AND REFERENCE INTERVALS IN EVALUATION OF MATERNAL THYROID FUNCTION

Abstract

The aim of this study was to introduce an estimation of thyroid dysfunction during pregnancy, selection of suitable analytic methods and determination of reference intervals for these markers in pregnancy. 1.The selection of efficient combination of methods for detection of thyroid dysfunction and the suitable term for investigation during pregnancy. Assess the interferences of other parameters, especially effect of high level of hCG on TSH. 2.Determination of the reference intervals for selected markers in the first trimester of pregnancy in plentiful group of pregnant women. 3.Defined reference intervals use to assign the percentage of thyroid dysfunction in the population of pregnant women who are undergoing their first trimester prenatal screening of the Down syndrome.

These women devolve on endocrinologist and especially pregnant women with anti-TPO positivity follow up also postpartum. 4.Verify statement about increased incidence of thyroid dysfunction in older pregnant women.