A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2

Abstract

A rat model of early sepsis induced by lipopolysaccharide (LPS) combined with interleukin-2 (IL-2) was developed. The primary aim was to assess the pharmacokinetics of gentamicin and sepsis-induced pathophysiological changes.

Moreover, the effects on the glomerular filtration rate and tubular function were studied in septic and control rats.

Keywords

• gentamicin
• sepsis
• pharmacokinetics
• LPSIL-2
• early endotoxemia
• multi-organ injury