Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity

Abstract

IgA nephropathy is characterized by circulating immune complexes composed of galactose-deficient IgA1 and glycan-specific IgG antibody, their deposit in the glomerular mesangium and mesangioproliferative glomerulonephritis. We found that the secreted IgG formed complexes with galactose-deficient IgA1 in a glycan-dependent manner.

We developed a dot-blot assay for the glycan-specific IgG antibody.

Keywords

• Galactose-deficient IgA1
• IgA1-containing immune comlexes
• o-Glycosilation
• mesangial cells
• purpura nephritis