Development of a human mitochondrial oligonucleotide microarray (h-MitoArray) and gene expression analysis of fibroblast cell lines from 13 patients with isolated FIFo ATP synthase deficiency

Abstract

We were interested in gene expression analysis of patient fibroblasts with mitochondrial ATP synhase deficiency of nuclear origin with unknown molecular basis and two patients with mutation in subunit 6

Keywords

• activated protein-kinase
• focused cDNA microarrays
• cytochrome- c-oxidase
• complex-I deficiency
• oxidative-phosphorylation
• replicative senescence integrative genomics
• binding protein
• skeletal-muscle
• disease