Abstract
As traditional risk factors are unable to fully explain the pathogenesis of coronary artery disease (CAD), novel mechanisms became a target of many investigations. The objective of our study was to investigate the response of selected markers to the physical exercise in CAD patients and healthy controls.
At rest, hs-CRP, AOPP, MMP-9 and BNP were significantly elevated in the CAD patients as compared with controls. In contrast, P-selectin values were significantly lower in CAD patients and a nonsignificant tendency to lower levels of sRAGE was also noted.
After exercise MMP-9 and BNP, increased significantly in both groups. Conclusions: CAD patients have elevated hs-CRP, AOPP, MMP-9 and BP - novel markers related to cardiovascular risk or left ventricular overload.
Only MMP-9 and BNP increase significantly with exercise both in healthy individuals and CAD patients.