Inhibition of Notch Signaling Prevents Experimental Fibrosis and Induces Regression of Established Fibrosis
2011
Abstract
The present results demonstrate that pharmacologic as well as genetic inhibition of Notch signaling exerts potent antifibrotic effects in different murine models of SSc. These findings might have direct translational implications because different inhibitors of the gama-secretase complex are available and have yielded promising results in cancer trials.