The role adipose of tissue in endothelial dysfunction, atherosclerosis and other complications of metabolic syndrome: influence of diet and pharmacotherapy
Abstract
The doctoral dissertation is focused on the role of adipose tissue in endothelial dysfunction and atherosclerosis. In the first part we have tested the effect of chronic rosiglitazone treatment on selected metabolic and hormonal parameters in patients with type 2 diabetes mellitus.
We have demonstrated that treatment with PPAR-γ agonist rosiglitazone for 5 month markedly improved diabetes compensation and circulating markers of endothelial dysfunction. The beneficial effect on endothelial dysfunction can very likely be explained by the combination of glucose-lowering effect of rosiglitazone and by increased circulating levels of anti-atherogenic hormone adiponectin.
In the second part we have studied the influence of chronic malnutrition in patients with anorexia nervosa on endocrine function of adipose tissue on both circulating and subcutaneous fat mRNA expression level. We have concluded, that local perturbations in resistin, adiponektin and IL-6 mRNA.