CYSL-1 interaguje s hydroxylázou EGL-9, která je senzorem kyslíku, a podporuje u C. elegans behaviorální plasticitu indukovanou hypoxií a modulovanou sirovodíkem

Abstrakt

This study shows a novel role for the nematode enzyme cysteine synthase (CYSL-1) in the signaling cascade of HIF-1 in response to hypoxia

Klíčová slova

• o-acetylserine sulfhydrylase
• cystathionine beta-synthase
• caenorhabditis-elegans
• hydrogen-sulfide
• inducible factor
• serine acetyltransferase
• guanylate cyclases
• active-site
• oxygen
• cysteine