Plasma Fatty Acid Composition in Patients with Pancreatic Cancer: Correlations to Clinical Parameters
2012
Abstract
Pancreatic cancer (PC) ranks as the fourth cause of cancer-related deaths in the Czech Republic. Evidence exists that deregu-lation of fatty acid (FA) metabolism is connected with some malig-nancies; therefore, we decided to analýze FA profile in plasma lipid classes in patients with PC with relation to tumor stag-ing, nutritional status, and survival.
The study included 84 patients (47 males, 37 females) with PC and 68 controls (36 males, 32 females). FA patterns were analyzed in plasma lipid classes by gas-chromatography.
We observed increased proportion of total monounsaturated FA (MUFA) in PC group in all plasma lipid classes.