The Peptidic GHS-R antagonist [D-Lys(3)]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity

Abstract

It was demonstrated that estrogen deficiency and consuming high fat (HF) diet enhanced orexigenic activity of ghrelin. Therefore, we hypothesized that antagonizing of ghrelin action would attenuate food intake and body weight in mice obese both from ovariectomy (OVX) and feeding a HF diet.

Keywords

• GHS-R
• [D-Lys(3)]GHRP-6
• [D-Arg(1), D-Phe(5), D-Trp(7,9), Leu(11)]sub P
• ovariectomized obese mice
• metabolic syndrome
• FGF21