Abstract
The current study aimed to evaluate plasma calprotectin levels and clearance end-stage renal disease (ESRD) patients with and without acute infection undergoing chronic hemodialysis (HD). Blood samples from 54 HD patients were obtained before and after the HD and 42 healthy blood donors were examined as controls.
The blood levels of calprotectin, procalcitonin, C-reactive protein (CRP), and intracellular production of interleukins 10 and 12 in monocytes were determined in both groups. The concentrations of plasma calprotectin in ESRD patients were significantly higher than in healthy controls (p < 0.05).
No differences between pre- and post-HD calprotectin plasma levels were observed (p = 0.07 for two-tailed test). Plasma calprotectin levels were not significantly influenced by the presence of acute infection (p = 0.19) or diabetes (p = 0.42).
A significant positive correlation of plasma calprotectin to plasma beta-2 microglobulin was proven (p < 0.05).