Inactivation of the Cannabinoid Receptor CB1 Prevents Leukocyte Infiltration and Experimental Fibrosis

Abstract

We demonstrate that the cannabinoid receptor CB1 is crucial for leukocyte infiltration and secondary fibroblast activation in experimental fibrosis and that inactivation of CB1 exerts potent anti-fibrotic effects. These findings might have direct translational implications because selective antagonists of CB1 that efficiently target CB1 in humans are available.

Keywords

• monocyte chemoattractant protein-1
• experimental dermal fibrosis
• systemic-sclerosis
• bone mass
• extracellular-matrix
• tissue
• pathogenesis
• fibroblasts
• scleroderma
• antagonists