Prion protein modulates cellular iron uptake: a novel function with implications for prion disease pathogenesis

Abstract

The article demonstrates that over-expression of PrPC increases intra-cellular iron. Neither PrPC nor the mutant PrP forms influence the rate or amount of iron released into the medium, suggesting a functional role for PrPC in cellular iron uptake

Keywords

• prion
• iron
• PrP
• PrPc