Hox genes and the limb development in the clinical praxis and in the experiment

Abstract

The review concentrates on the role of HOX genes in limb development and birth defects caused by mutations of these genes. It compares data obtained on experimental models with clinical genetics case reports in humans.

Keywords

• HOX
• congenital birth defect
• limb development
• hand-foot-genital syndrome
• synpolydactyly