Abstract
Epsilon gene for apolipoprotein E (APOE) belongs among the most studied so called "candidate genes of longevity". The association of APOE polymorfism is proved in relation to many diseases (hypercholesterolaemia, cardiovascular disease, Alzheimer disease), thus we tried to evaluate the relation of APOE polymorfism and senior fitness.
Our pilot study proved statisticaly significant relation (p = 0,0248) between allele E4 and functional fitness in senior age. According to the results of logistic regression, the carriers of allele E4 (i.e.
E2/E4, E3/E4 and E4/E4) have 13x higher risk of functional unfitness than individuals with genotype E2/E3.