Dipeptidyl peptidáza-IV v synoviální tekutině a na mononukleárních buňkách synoviální tekutiny pacientů s revmatoidní artritidou

Abstrakt

Dipeptidyl peptidase-IV (DPP-IV) enzymatic activity controls biological halftime of multiple local mediators. Its deregulation is associated with pathogenesis of several autoimmune diseases, including rheumatoid arthritis (RA).

We reported decrease of DPP-IV/CD26 in CD3+ synovial fluid mononuclear cells in RA, which also negatively correlate with SDF concentration in synovial fluid.

Klíčová slova

• Rheumatoid arthritis
• Dipeptidyl peptidase
• Synovial fluid mononuclear cells
• DASH
• Stromal cell-derived factor-1