EBV plus diffuse large B-cell lymphoma arising within atrial myxoma. An example of a distinct primary cardiac EBV plus DLBCL of immunocompetent patients
2012
Abstract
Cardiac myxoma and diffuse lange B-cell lumphona. The lymphomas arising within myxoma may follow a pathogenic pathway driven by EBV, whose transformation potential is unleashed in the cytokine-rich milieu of a myxoma, presumably accentuating age-related decline of adaptive immunity known as immune senescence.
DLBCL arising within atrial myxoma grouped together with EBV+DLBCL associated with valve prosthesis and with an atrial thrombus differs in the immunocompetent patrients from primary cardiac DLBCL. Distinction between these groups may have important therapeutic consequences.