N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin. I. New synthesis, physicochemical characterization and preliminary biological evaluation

Abstract

New method using methacrylamide-type comonomers, containing either hydrazide group or hydrazon of DOX for synthesis of HPMA conjugates with pH-controlled activation of doxorubicin

Keywords

• Copolymerization
• drug-delivery systems
• water-soluble polymers
• radical polymerization
• doxorubicin