Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase

Abstrakt

The results suggest that peripheral nervous system AChE is a major target of AChE inhibitors, and that its absence in AChE-deficient mice is the main cause of the slow development and vulnerability of these mice. At level of the brain, the adaptation to the absence of AChE is nearly complete.

Klíčová slova

• acetylcholine
• Alzheimer's disease
• autonomous nervous system
• cholinergic receptors
• microdialysis
• mouse genetics