The analysis of factors affecting the threshold on repeated F-18-FDG-PET/CT investigations measured by the PERCIST protocol in patients with esophageal carcinoma
2012
Abstrakt
When applying the PET Response Criteria in Solid Tumors protocol, a threshold value based on standardized uptake value corrected to lean body mass (SUL) in liver parenchyma, or in the blood pool, is used: to metabolically specify a measurable lesion; to calculate metabolic tumor volume (mTV) and its product total lesion glycolysis (TLG); and as a limit for response measurement. The problem with using changes in glucose metabolism as a marker for response to therapy is its reproducibility on test-retest examinations.
Klíčová slova
esophageal carcinoma 2-deoxy-2-[F-18]fluoro-D-glucose neoadjuvant chemotherapy positron emission tomography Response Criteria in Solid Tumors positron emission tomography/computed tomography reproducibility threshold positron-emission-tomography whole-body pet esophagogastric junction neoadjuvant therapy malignant-tumors uptake values cancer reproducibility chemotherapy trials