SUG-1 Plays Proteolytic and Non-proteolytic Roles in the Control of Retinoic Acid Target Genes via Its Interaction with SRC-3

Abstract

Nuclear retinoic acid receptor alpha (RAR alpha) activates gene expression through dynamic interactions with coregulatory protein complexes, the assembly of which is directed by the ligand and the AF-2 domain of RAR alpha. Then RAR alpha and its coactivator SRC-3 are degraded by the proteasome.

Keywords

• Ubiquitin-proteasome pathway
• nuclear receptors
• mediated transcription
• 26S proteasome
• atpase SUG1
• RAR-alpha