The Genetics of Parkinson's Disease

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting more than 1% of the population over the age of 60 years. PD is caused by loss of dopaminergic neurons in the substantia nigra pars compacta

Keywords

• Parkinson's disease
• genetics
• mutation
• molecular pathology
• early-onset parkinsonism
• endoplasmic-reticulum stress
• mitochondrial-dna deletions
• ubiquitin-protein ligase
• substantia-nigra neurons
• alpha-synuclein
• lewy body
• oxidative stress
• up-regulation
• cell-death